1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. ATP Synthase

ATP Synthase (ATP合酶)

ATPases are a class of enzymes that catalyze the decompositionof ATP into ADP and a free phosphate ion. This dephosphorylation reaction releases energy, which the enzyme (in most cases) harnesses to drive other chemical reactions that would not otherwise occur. Some such enzymes are integral membrane proteins and move solutes across the membrane, typically against their concentration gradient. These are called transmembrane ATPases. Transmembrane ATPases import many of the metabolites necessary for cell metabolism and export toxins, wastes, and solutes that can hinder cellular processes. Such as the sodium-potassium exchanger (or Na+/K+ ATPase) and the hydrogen potassium ATPase (H+/K+ ATPase or gastric proton pump) that acidifies the contents of the stomach.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-113038
    D-α-Hydroxyglutaric acid

    2-羟基-D-谷氨酸; (R)-2-羟基戊二酸

    Inhibitor
    D-α-Hydroxyglutaric acid ((R)-2-Hydroxyglutarate) 是神经代谢疾病 D-2-羟基戊二酸尿症中积累的主要代谢产物。D-α-Hydroxyglutaric acid 是 α-酮戊二酸 (α-KG) 的弱竞争拮抗剂,可抑制多种 α-KG 依赖性双加氧酶 (dioxygenases),Ki 为 10.87 mM。D-α-Hydroxyglutaric acid 可增加活性氧 (ROS) 的产生。D-α-Hydroxyglutaric acid 还可结合并抑制 ATP 合酶并抑制 mTOR 信号传导。
    D-α-Hydroxyglutaric acid
  • HY-121908
    FCPT Inhibitor
    FCPT 是 ATP 的竞争性抑制剂,在不改变微管动力学的情况下,诱导肌动蛋白-5与微管紧密结合,并选择性地诱导爪蟾提取物纺锤体极处的微管丢失。
    FCPT
  • HY-N8265
    Abyssinone V Inhibitor
    Abyssinone V 是一种异戊二烯化类黄酮,具有预测的抗病毒活性。Abyssinone V 可以从 Erythrina melanacantha 的茎皮中分离出来。Abyssinone V 具有良好的药效学特性。Abyssinone V 被预测为抗病毒剂,包括抗疱疹 (HSV)。其机制包括抑制聚合酶、ATP 酶和膜完整性。
    Abyssinone V
  • HY-125637
    Venturicidin B Inhibitor
    Venturicidin B (Aabomycin A2) 是一种从链霉菌中分离出来的大环内酯类抗生素,可用作抗真菌剂,线粒体 F0-ATP 合成酶(ATP synthase)复合体的有效抑制剂。
    Venturicidin B
  • HY-N12486
    Isofalcarintriol Inhibitor
    Isofalcarintriol 是一种 NRF2 激活剂和线粒体ATP合成酶 (mitochondrial ATP synthase) 的选择性抑制剂。Isofalcarintriol 可用于衰老研究。
    Isofalcarintriol
  • HY-157046
    ATP Synthesis-IN-2 Inhibitor
    ATP Synthesis-IN-2 (Compound 5) 具有抗菌活性。ATP Synthesis-IN-2有效的 ATP 合成活性抑制剂,对 Pseudomonas aeruginosa (PA) 的 IC50 值为 0.7 μg/mL。
    ATP Synthesis-IN-2
  • HY-157045
    ATP Synthesis-IN-1 Inhibitor
    ATP Synthesis-IN-1 (Compound 4) 是喹啉衍生物,是 PA ATP 合成活性的有效抑制剂。 ATP Synthesis-IN-1 具有 PA ATP 合成抑制作用,IC50 值为 11.1μg/mL。ATP Synthesis-IN-1 还具有抗菌活性。 ATP Synthesis-IN-1可用于耐药PA感染的研究。
    ATP Synthesis-IN-1
  • HY-162804
    ATP synthase inhibitor 3 Inhibitor
    ATP synthase inhibitor 3 (compound PT6) 是一种具有口服活性的分枝杆菌 F-ATP 合酶 (IC50=0.788μM) 抑制剂。ATP synthase inhibitor 3 在体外抑制 Mycobacterium tuberculosis H37Rv 菌株 (ATCC-27294) 的生长,并在 IC50 值为 30 μM 时耗尽细胞内 ATP 水平。
    ATP synthase inhibitor 3
  • HY-155754
    3′-Acetate-ATP Inhibitor
    3’-Acetate-ATP 是 ATP 类似物,是 ATP 乙酰化产物,在 259 nm 处具有最大紫外线吸收 (中性 pH 值的水中)。3’-Acetate-ATP 对核酸聚合发挥阻断作用。
    3′-Acetate-ATP
目录号 产品名 / 同用名 应用 反应物种